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The postnatal acquisition of factors which affect the influenza haemagglutination-inhibition test

Identifieur interne : 000101 ( Istex/Curation ); précédent : 000100; suivant : 000102

The postnatal acquisition of factors which affect the influenza haemagglutination-inhibition test

Auteurs : P. C. A. Grint ; S. Argent ; R. B. Heath

Source :

RBID : ISTEX:D04F53A325169C499F28DADA383DA39359DB892B

Abstract

Levels of maternally transferred antibodies against the surface antigen of the A/Texas/1/77 strain of influenza virus showed the expected decline during infancy when measured by complement fixation (CF). However, this decline was not observed when these antibodies were measured by haemagglutination-inhibition (HI). It has been postulated that this discrepancy is due to the acquisition, in the early days of life, of non-specific serum factors which increase the HI activity of sera. The levels of these factors were determined indirectly by calculating HI: CF ratios and it was shown that the factors are rapidly acquired by children between the fifth and twentieth week of life.

Url:
DOI: 10.1017/S0022172400070868

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ISTEX:D04F53A325169C499F28DADA383DA39359DB892B

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P. C. A. Grint
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S. Argent
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R. B. Heath
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<div type="abstract">Levels of maternally transferred antibodies against the surface antigen of the A/Texas/1/77 strain of influenza virus showed the expected decline during infancy when measured by complement fixation (CF). However, this decline was not observed when these antibodies were measured by haemagglutination-inhibition (HI). It has been postulated that this discrepancy is due to the acquisition, in the early days of life, of non-specific serum factors which increase the HI activity of sera. The levels of these factors were determined indirectly by calculating HI: CF ratios and it was shown that the factors are rapidly acquired by children between the fifth and twentieth week of life.</div>
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