The postnatal acquisition of factors which affect the influenza haemagglutination-inhibition test
Identifieur interne : 000101 ( Istex/Curation ); précédent : 000100; suivant : 000102The postnatal acquisition of factors which affect the influenza haemagglutination-inhibition test
Auteurs : P. C. A. Grint ; S. Argent ; R. B. HeathSource :
- Journal of Hygiene [ 0022-1724 ] ; 1982-10.
Abstract
Levels of maternally transferred antibodies against the surface antigen of the A/Texas/1/77 strain of influenza virus showed the expected decline during infancy when measured by complement fixation (CF). However, this decline was not observed when these antibodies were measured by haemagglutination-inhibition (HI). It has been postulated that this discrepancy is due to the acquisition, in the early days of life, of non-specific serum factors which increase the HI activity of sera. The levels of these factors were determined indirectly by calculating HI: CF ratios and it was shown that the factors are rapidly acquired by children between the fifth and twentieth week of life.
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DOI: 10.1017/S0022172400070868
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P. C. A. Grint<affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE</mods:affiliation>
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<affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE</mods:affiliation>
<wicri:noCountry code="subField">7BE</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Virology Department, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE</mods:affiliation>
<wicri:noCountry code="subField">7BE</wicri:noCountry>
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<front><div type="abstract">Levels of maternally transferred antibodies against the surface antigen of the A/Texas/1/77 strain of influenza virus showed the expected decline during infancy when measured by complement fixation (CF). However, this decline was not observed when these antibodies were measured by haemagglutination-inhibition (HI). It has been postulated that this discrepancy is due to the acquisition, in the early days of life, of non-specific serum factors which increase the HI activity of sera. The levels of these factors were determined indirectly by calculating HI: CF ratios and it was shown that the factors are rapidly acquired by children between the fifth and twentieth week of life.</div>
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